Luminescent platforms for monitoring changes in the solubility of amylin and huntingtin in living cells.
نویسندگان
چکیده
Luminescent, cell-based assays capable of monitoring the aggregation potential of the disease-relevant proteins known as amylin (type 2 diabetes) and huntingtin (Huntington's disease) are presented. These sensitive platforms report on the influence of mutations as well as small molecules on protein solubility.
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عنوان ژورنال:
- Molecular bioSystems
دوره 12 10 شماره
صفحات -
تاریخ انتشار 2016